Endocrine Abstracts

Background, subjects & methods: Dexamethasone increases visfatin synthesis in vitro, but it is not clear, whether it is reflected in the changes of serum levels of this cytokine. We have therefore assessed fasting serum concentrations of visfatin, glucose, insulin and cortisol in 20 subjects (4 males, 5 subjects with type 2 diabetes) age (mean±S.D.) 42.1±17.2 years, BMI 36,7±8.38 kg/m2 before and after 48 hours of administrat...

Background, subjects & methods: Visfatin, also known as pre-B cell colony enhancing factor (PBEF), is a cytokine that is highly expressed in visceral fat, and exerts insulin-mimicking effects in rodents through activation of an insulin receptor, though in a manner distinct from insulin. Visfatin levels do not change in response to acute hyperinsulinaemia in mice, but it is not clear whether this also applies to humans. In order to investigate this we measured serum visfati...

The effectiveness of thyroid remnants ablation with 131I after thyroidectomy for differentiated thyroid carcinoma (DTC) depends mainly on absorbed radiation dose, which is proportional to 131I uptake (Tup) and its effective half-life time (EHL) in the remnants.Aim: Assessment of endogenous TSH level increment effects on EHL of 131I and Tup in thyroid remnants after surgery for DTC.Material: Twenty-o...

It is recognized that a substantial proportion of patients found to have raised prolactin (PRL) level on a single testing is subsequently found to have normal PRL levels. Though this is often attributed to stress or medication factor, it should be noted, that PRL secretion displays diurnal variation with a nocturnal peak in the late-night/early morning hours. In our study we tested the hypothesis, that in some patients raised PRL levels in the morning may reflect individual di...

BackgroundThere is no universal consensus regarding vitamin sufficiency status with values either above 20 ng/ml, or 30 ng/ml being quoted as denoting ’sufficient’ status. We have endeavoured to assess the effects of summer sunshine exposure on vitamin D status from a single GP practice in central Poland.Subjects and methodsWe measured concentrations of vitamin D, parathyroid hormone (PTH), creatini...

Back groundBoth pregnancy and polycystic ovary syndrome (PCOS) constitute insulin-resistant states, while gestational diabetes (GDM) is associated with adverse pregnancy outcomes. Though screening for GDM is typically performed later in pregnancy, some women demonstrate significant insulin resistance (IR) and develop GDM even in 1st trimester. We have endeavoured to compare surrogate IR indices in 1st trimester pregnant women and in...

Introduction: Graves’ disease (GD), similarly to most autoimmune disease, is triggered by environmental factors in genetically predisposed individuals. Particular HLA alleles increase or decrease GD risk. We have recently demonstrated novel, previously not reported association between a presence of alleles HLA-B*39:06, -B*37:01, -C*14:02, -C*03:02, -C*17:01, -DRB1*14:01 and GD. These alleles are independent risk factors, with no linkage disequilibrium with other,...

Introduction: Subacute thyroiditis is a thyroid inflammatory disease, triggered mainly by viral factors in genetically susceptible individuals. Up to 2020, only HLA-B*35 was confirmed as SAT-related. However, obviously in HLA-B*35-negative patients, some other genetic background occurs. Material and Methods: We performed HLA-typing using high resolution NGS method in different groups of patients with SAT and demonstrated the new association between HLA a...

Background: Copeptin (pre-proAVP) secreted in equimolar amounts with vasopressin (AVP) closely reflects AVP release. Previously it was shown that copeptin is stimulated in standard pituitary function tests acting through hypothalamic centres. Furthermore, copeptin has been shown to subtly mirror stress potentially mediated via CRH. To further test a potential direct interaction of CRH with copeptin release which could augment AVP effects on pituitary function, we investigated ...

Introduction: TSH seems to play direct role in bone metabolism. TSH receptors are expressed on osteoblasts and osteoclast precursors. Osteocalcin (OC) is well known marker of bone formation, whereas collagen type I crosslinked C-telopeptide I (CTX) is marker of bone resorption. Sclerostin is a protein, recently found to inhibit bone formation, while parathormone (PTH) inhibits sclerostin production. The aim of the study was to estimate sclerostin, OC, CTX and PTH levels after ...